Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study.

Abstract

The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs with Pgp activity and exposure to… (More)
DOI: 10.1111/tri.12018

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@article{Llaud2013DoDT, title={Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study.}, author={In{\'e}s Llaud{\'o} and Helena Colom and Pepita Gim{\'e}nez-Bonaf{\'e} and Juan Torras and Anna Cald{\'e}s and Maria J. Sarrias and Josep Mar{\'i}a Cruzado and Federico Oppenheimer and Jaime S{\'a}nchez-Plumed and Miguel {\'A}ngel Gentil and H. B. N. Ekberg and Josep Mar{\'i}a Grinyo and N{\'u}ria Lloberas}, journal={Transplant international : official journal of the European Society for Organ Transplantation}, year={2013}, volume={26 2}, pages={177-86} }