Do cells need CDK2 and...Bcr-Abl?

  title={Do cells need CDK2 and...Bcr-Abl?},
  author={Mikhail V. Blagosklonny},
  journal={Cell Death and Differentiation},
Until recently, the central role of CDK2 in the G1/S transition was unshakable dogma. Even a recent publication noting that CDK2 activity is not necessary for proliferation of cancer cells was not terribly surprising. In cancer cells, alterations in tumor suppressors and oncogenes result in loss of the restriction point of the cell cycle. Thus, for example, overexpression of E2F and c-Myc alone can drive G1/S progression. It was predicted that some cancers do not need CDK2 or CDK4 and that… CONTINUE READING

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Bcr-Abl inhibits apoptosis. By multiple mechanisms, Bcr-Abl inhibits caspases and activates CDKs Figure 2 The dam model

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Oncogene • 2002

News and Commentary 251 Cell Death and Differentiation

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J. Natl. Cancer Inst • 2000

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