Do blue light filters confer protection against age-related macular degeneration?
@article{Margrain2004DoBL, title={Do blue light filters confer protection against age-related macular degeneration?}, author={Tom H. Margrain and Michael E. Boulton and John Marshall and David H Sliney}, journal={Progress in Retinal and Eye Research}, year={2004}, volume={23}, pages={523-531} }
223 Citations
Current concept of the pathogenesis of age-related macular degeneration: the role of oxidative stress and inflammation
- Biology, Medicine
- 2006
A ran-domized, prospective, placebo-controlled study in United States showed that high-dose supplementation of beta-caroten, vitamin C, vitamin E, copper, and zinc significantly slowed the progression of the disease and visual deterioration in patients with AMD.
Age-related macular degeneration (AMD): pathogenesis and therapy.
- Biology, MedicinePharmacological reports : PR
- 2006
Four processes: lipofuscinogenesis, drusogenesis, inflammation and neovascularization, specifically contribute to the development of two forms of AMD, the dry form (non-exudative; geographic atrophy) and the wet form (Exudative, nevascular).
Age-related maculopathy and the impact of blue light hazard.
- Medicine, BiologyActa ophthalmologica Scandinavica
- 2006
The Age-Related Eye Disease Study (AREDS), a randomized clinical trial, showed a significantly lower incidence of late ARM in a cohort of patients with drusen maculopathy treated with high doses of antioxidants than in a placebo group, creating a platform for the search for new prophylactic and therapeutic measures to alleviate or prevent photoreceptor and RPE degeneration in ARM.
Emerging innovations in nano-enabled therapy against age-related macular degeneration: A paradigm shift.
- Biology, MedicineInternational journal of pharmaceutics
- 2021
Intraocular lens short wavelength light filtering
- MedicineClinical & experimental optometry
- 2010
A review looks at the risks and the benefits of filtering out short wavelength light in pseudophakic patients, which includes ultraviolet, blue and violet wavelengths.
Systemic changes in neovascular age-related macular degeneration.
- Biology, MedicineDanish medical journal
- 2014
The results suggest that inadequate systemic immune modulation is an important pathogenic mechanism in the aetiology of AMD, proposing that different mechanisms may underlie the different subtypes of AMD.
Recent developments in age-related macular degeneration: a review
- MedicineClinical interventions in aging
- 2017
The role of anti-vascular endothelial growth factor (anti-VEGF) agents has transformed the therapeutic approach of the potentially blinding disease “wet AMD” into a more favorable outcome.
Oxidative Stress Induced Damage of the Human Retina: Overview of Mechanisms and Preventional Strategies
- Biology, Medicine
- 2012
It is shown that many studies in cell and molecular biology, animal experiments and first clinical trials point to a preferential use of yellow tinted lenses especially in the elderly and ARMD patients, and studies showing that the shortwave part of the visible spectrum of light can be harmful to the retina, especially to the macula and optic nerve are referred to.
Surgery for macular disease
- Medicine
- 2011
The rationale of surgery in both techniques is to effectively restore the choriocapilliaris-Bruch’s-RPE interface beneath the foveal photoreceptors and rescue function before fibrovascular proliferation causes marked ‘irreversible’ photoreceptor loss.
Drugs in Phase II clinical trials for the treatment of age-related macular degeneration
- Biology, MedicineExpert opinion on investigational drugs
- 2015
This review provides an overview of the agents that are in mid-stage phase trials for both exudative (wet) and nonexudative macular degeneration (dry AMD) and the goal is to develop a strategy to slow or stop progressive loss of retinal tissue seen in geographic atrophy, the hallmark of advanced dry AMD.
References
SHOWING 1-10 OF 69 REFERENCES
Macular pigment and age related macular degeneration
- MedicineThe British journal of ophthalmology
- 1999
The current literature germane to macular pigment and AMD is reviewed, and the evidence that retinal carotenoids are protective against AMD is examined to indicate that oxidative damage plays a role.
Exposure to sunlight and other risk factors for age-related macular degeneration.
- MedicineArchives of ophthalmology
- 1989
It was found that in phakic subjects, even with high levels of sunlight exposure, there was no evidence of increased risk of age-related macular degeneration associated with UV-B or UV-A exposure.
Visible light and risk of age-related macular degeneration.
- MedicineTransactions of the American Ophthalmological Society
- 1990
Analysis of detailed histories of ocular sun exposure in 838 watermen who work on the Chesapeake Bay suggests that high levels of exposure to blue and visible light late in life may be important in causing AMD.
Artificial light and early-life exposure in age-related macular degeneration and in cataractogenic phototoxicity.
- BiologyArchives of ophthalmology
- 1993
It is reported that visible light, particularly blue light, may be a risk factor for age-related macular degeneration (ARMD) based on possible photo-oxidative stress, although no equivalent risk was found for UV-B or UV-A exposure.
Blue Light-induced Reactivity of Retinal Age Pigment
- BiologyThe Journal of Biological Chemistry
- 1995
It is postulate that lipofuscin is a potential photosensitizer that may increase the risk of retinal photodamage and contribute to the development of age-related maculopathy.
Sunlight and age-related macular degeneration. The Beaver Dam Eye Study.
- MedicineArchives of ophthalmology
- 1993
Exposure to sunlight may be associated with age-related maculopathy, however, longitudinal studies of these associations are needed.
Spare the rods, save the cones in aging and age-related maculopathy.
- MedicineInvestigative ophthalmology & visual science
- 2000
The functional studies reviewed herein were facilitated by the development of standard fundus grading systems, which permit comparison of results from patients at similar stages of ARM across disciplines, and a better understanding of the mechanisms underlying normal human dark adaptation, which informs the interpretation of ageand diseaserelated changes.
The long-term effects of visible light on the eye.
- Medicine, Environmental ScienceArchives of ophthalmology
- 1992
It is suggested that high levels of exposure to blue or visible light may cause ocular damage, especially later in life, and may be related to the development of age-related macular degeneration.
Sun exposure and age-related macular degeneration. An Australian case-control study.
- MedicineOphthalmology
- 1997