Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?

@article{McAlindon1996DoAM,
  title={Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?},
  author={Timothy E. McAlindon and Paul H. Jacques and Yuqing Zhang and Marian T Hannan and Piran Aliabadi and Barbara N. Weissman and D Rush and Dan Levy and David T Felson},
  journal={Arthritis and rheumatism},
  year={1996},
  volume={39 4},
  pages={
          648-56
        }
}
OBJECTIVE Cumulative damage to tissues, mediated by reactive oxygen species, has been implicated as a pathway that leads to many of the degenerative changes associated with aging. We hypothesized that increased intake of antioxidant micronutrients might be associated with decreased rates of osteoarthritis (OA) in the knees, a common age-related disorder. METHODS Participants in the Framingham Osteoarthritis Cohort Study underwent knee evaluations by radiography at examinations 18 (1983-1985… CONTINUE READING

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