Do We Need to Detect Isoniazid Resistance in Addition to Rifampicin Resistance in Diagnostic Tests for Tuberculosis?

@inproceedings{Denkinger2014DoWN,
  title={Do We Need to Detect Isoniazid Resistance in Addition to Rifampicin Resistance in Diagnostic Tests for Tuberculosis?},
  author={Claudia M Denkinger and Madhukar Pai and David W. Dowdy},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Multidrug-resistant tuberculosis (MDR-TB) is resistant to both rifampicin (RIF) and isoniazid (INH). Whereas many TB diagnostics detect RIF-resistance, few detect INH-monoresistance, which is common and may increase risk of acquired MDR-TB. Whether inclusion of INH-resistance in a first-line rapid test for TB would have an important impact on MDR-TB rates remains uncertain. METHODS WE DEVELOPED A TRANSMISSION MODEL TO EVALUATE THREE TESTS IN A POPULATION SIMILAR TO THAT OF INDIA: a… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 50 references

Comparing cost-effectiveness of standardized TB treatments given varying drug-resistance

  • S Law, A Benedetti, O Oxlade, K Schwartzman, D Menzies
  • Eur Respir J
  • 2013
Highly Influential
14 Excerpts

Infectious diseases of humans: dynamics and control

  • RM Anderson, RM May
  • 1991
Highly Influential
14 Excerpts

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