Do We Need Worms to Promote Immune Health?

@article{Weinstock2015DoWN,
  title={Do We Need Worms to Promote Immune Health?},
  author={Joel V. Weinstock},
  journal={Clinical Reviews in Allergy \& Immunology},
  year={2015},
  volume={49},
  pages={227-231}
}
  • J. Weinstock
  • Published 1 October 2015
  • Biology, Medicine
  • Clinical Reviews in Allergy & Immunology
Many immune-mediated diseases like inflammatory bowel disease, multiple sclerosis, type 1 diabetes, asthma, and food allergy appeared to have increased in frequency in developed countries in the latter part of the twentieth century. Reports from less developed countries suggest that the “epidemic” of immune-mediated diseases now is spreading into these regions as well. The “hygiene hypothesis” was developed to partly explain this phenomenon. It has been proposed that modern-day sanitary living… 

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References

SHOWING 1-10 OF 45 REFERENCES

Allergy, parasites, and the hygiene hypothesis.

The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders.

Helminth Infections Decrease Host Susceptibility to Immune-Mediated Diseases

Investigators are identifying key helminth-derived immune modulatory molecules that may have therapeutic usefulness in the control of inflammatory disease.

Does the failure to acquire helminthic parasites predispose to Crohn's disease?

It is proposed that exposure to an environmental agent predisposes individuals to Crohn's disease and the Th2 response provoked by parasitic worms can modulate immune reactions to unrelated parasitic, bacterial, and viral infections.

Helminths and harmony

Support for the “IBD hygiene hypothesis” is lent by reporting in this issue of Gut that infection with the helminth Schistosoma mansoni protects rats from trinitrobenzene sulphonic acid (TNBS) induced colitis.

Heligmosomoides polygyrus Infection Can Inhibit Colitis through Direct Interaction with Innate Immunity

These experiments infer that H. polygyrus does not require direct interactions with T or B cells to render animals resistant to colitis, and suggest that phenotypic alternations in mucosal DC function are part of the regulatory process.

Helminths as governors of inflammatory bowel disease

A real life scenario is presented, which supports the impact of helminths in the prevention of IBD, and a rationale for the mechanisms of action is provided.

A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors

If CD patients tolerate hookworm infection, and the practical issues associated with establishing reservoir donors (RDs) are tested.

Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms1

Findings indicate that helminth molecules exert potent regulatory effects on both DCs and B cells through TLR2 regulation conducted via different signaling pathways, which could prove critical in developing novel therapeutic approaches for the treatment of autoimmune diseases such as MS.

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

It is shown that helminths have been a major selective force on a subset of interleukin (IL)/IL receptor genes (IL genes), and six risk alleles for inflammatory bowel (IBD) or celiac disease are significantly correlated with micropathogen richness, which support the hygiene hypothesis for IBD and provide a large set of putative targets for susceptibility to helminth infections.

Why is type 1 diabetes increasing?

  • F. Egro
  • Medicine
    Journal of molecular endocrinology
  • 2013
A review of some of the most well-known theories found in the literature: hygiene, viral, vitamin D deficiency, breast milk and cow's milk hypotheses, which suggest that a multifactorial process might be involved in the incidence of type 1 diabetes.