Do Sigma Factors Need Help with a Meltdown?

  title={Do Sigma Factors Need Help with a Meltdown?},
  author={Ruth M. Saecker and Caroline A. Davis and M. Thomas Record},
In this issue of Cell, Hsu et al. (2006) report on the binding activity of a variant of the bacterial transcriptional specificity factor sigma (sigma) to promoter DNA. This study demonstrates that the sigma variant induces a large distortion in the transcriptional start site in the absence of core RNA polymerase, raising intriguing new questions about the… CONTINUE READING