Do Selective Serotonin Reuptake Inhibitors (SSRIs) Cause Fractures?

@article{Warden2016DoSS,
  title={Do Selective Serotonin Reuptake Inhibitors (SSRIs) Cause Fractures?},
  author={Stuart J. Warden and Robyn K. Fuchs},
  journal={Current Osteoporosis Reports},
  year={2016},
  volume={14},
  pages={211-218}
}
Recent meta-analyses report a 70 % increase in fracture risk in selective serotonin reuptake inhibitor (SSRI) users compared to non-users; however, included studies were observational and limited in their ability to establish causality. Here, we use the Bradford Hill criteria to explore causality between SSRIs and fractures. We found a strong, consistent, and temporal relationship between SSRIs and fractures, which appears to follow a biological gradient. However, specificity and biological… Expand
Use of Selective Serotonin Reuptake Inhibitors and Risk of Hip Fracture in the Elderly: A Case-Control Study in Taiwan.
TLDR
Current use of SSRIs was associated with a 2.17-fold increase in the odds of hip fracture in the elderly in Taiwan, and Clinicians should consider the possibility of SSRI-associated hip fracture among old people currently taking SSRI. Expand
Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells.
TLDR
These data suggest osteoclasts are a likely target of bone homeostasis disruption due to sertraline treatment, most potently through the osteoblast/clast feedback loop. Expand
Drug treatment strategies for osteoporosis in stroke patients
TLDR
Doctors should bear in mind that drugs commonly used for stroke, such as statins or warfarin, may have beneficial or adverse effects on BMD and fracture risks. Expand
What are the complications and emerging strategies for preventing depression following traumatic brain injury?
TLDR
The authors review the efficacy of sertraline, a selective serotonin reuptake inhibitor (SSRI), for the prevention of new cases of depression in the first six months after TBI and other studies on preventive strategies in PTBID as ascertained from a PubMed and citation search. Expand
Association Between Antidepressant Drug Use and Hip Fracture in Older People Before and After Treatment Initiation
TLDR
An association between antidepressant drug use and hip fracture before and after the initiation of therapy is found and raises questions about the association that should be further investigated in treatment studies. Expand
The psychopharmacology of brain vascular disease/poststroke depression.
TLDR
Given the prevalence of PSD, preventive pharmacologic strategies may be effective alternatives and the choice of treatment will be determined by the type and severity of medical and psychiatric comorbidities as well as the preferences of the patient. Expand
Interactions of antidepressants, mood-stabilisers and antipsychotics with food
TLDR
Review and analysis of interactions between food and antidepressants, mood stabilisers and antipsychotics found food containing tyramine was shown to interact with MAO inhibitors altering their pharmacodynamic properties, and appropriate care and consideration must be taken when attempting to extrapolate results of in vitro or animal studies to humans. Expand
Exploring risk for fracture and osteoarthritis
Objective: Hip fracture is the most serious condition linked to low bone mass or osteoporosis, and Sweden has one of the highest incidences in the world. The proportion of elderly is increasing inExpand
Hearing impairment increases the risk of distal radius, hip, and spine fractures: A longitudinal follow-up study using a national sample cohort
TLDR
The risk of distal radius fracture, hip fracture, and spine fracture was increased in the severe hearing-impaired group compared with the control group and this study aimed to delineate the risk of each fracture type in all age populations. Expand
Gut‐derived serotonin contributes to bone deficits in colitis☆
TLDR
Findings from both the DSS and SERT−/− mouse models support a contributing role for 5‐HT as a significant factor in bone loss induced by colitis. Expand
...
1
2
...

References

SHOWING 1-10 OF 94 REFERENCES
Effect of selective serotonin reuptake inhibitors on the risk of fracture.
TLDR
Daily SSRI use in adults 50 years and older remained associated with a 2-fold increased risk of clinical fragility fracture after adjustment for potential covariates. Expand
Osteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome
TLDR
Evidence from longitudinal, cross-sectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density and increased fracture risk, and the evidence now seems sufficient to consider adding SSRIs to the list of medications that contribute to osteoporosis. Expand
Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case–control studies
TLDR
The SSRIs may exert an increased risk of fracture independent of depression and bone mineral density and the overall association between SSRI use and fracture risk was weaker. Expand
Use of selective serotonin reuptake inhibitors and risk of fracture: A systematic review and meta‐analysis
TLDR
A meta‐analysis of 12 observational studies showed that the overall risk of fracture was higher among people using SSRIs and the strength of the association decreased with a longer window of SSRI administration before the index date. Expand
Cause or Effect? Selective Serotonin Reuptake Inhibitors and Falls in Older Adults: A Systematic Review.
TLDR
There is no Level 1 evidence thatSSRIs cause falls, and changes in the current treatment guidelines or policies on the use of SSRIs in older adults based on fall risk may not be justified at this time given the lack of an established evidence base. Expand
Adherence to Treatment with Selective Serotonin Reuptake Inhibitors and the Risk for Fractures and Bone Loss
TLDR
Exposure to SSRI treatment is associated with an increased risk of bone loss-related events and further studies are required to determine the causality of the association and its relevance to the clinical use of SSRIs. Expand
Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture.
TLDR
The authors have performed a case-control analysis and a self-controlled case-series analysis using 1987-1999 diagnosis data for 16,341 cases of hip fracture and 29,889 controls drawn from the United Kingdom General Practice Research Database, showing an association between hip fractures and antidepressant treatment. Expand
Fracture Risk From Psychotropic Medications: A Population-Based Analysis
Background: Selective serotonin reuptake inhibitors (SSRIs), benzodiazepines, and antipsychotics have each been associated with an increased risk of fracture in older individuals. The aim of thisExpand
Selective Serotonin Reuptake Inhibiting Antidepressants Are Associated With an Increased Risk of Nonvertebral Fractures
TLDR
Not only users of TCAs but also of SSRIs have a significantly increased risk of nonvertebral fractures, in SSRI users especially after prolonged use, and physicians treating elderly depressive patients should be aware of the unfavorable long-term consequence of SSRs on fracture risk. Expand
Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density?
TLDR
Current findings suggest a link between mental illness and osteoporosis that is of clinical relevance and treatment algorithms need to recognize this association to ensure that vulnerable populations are screened. Expand
...
1
2
3
4
5
...