Do RANKL inhibitors (denosumab) affect inflammation and immunity?

  title={Do RANKL inhibitors (denosumab) affect inflammation and immunity?},
  author={Sylvie Ferrari-Lacraz and Stefania Ferrari},
  journal={Osteoporosis International},
Receptor activator of nuclear factor kappa B ligand (RANKL) and its natural antagonist, osteoprotegerin (OPG), are, respectively, an indispensable factor and a potent inhibitor for osteoclast differentiation, activity, and survival. The development of a human monoclonal antibody to RANKL, denosumab, constitutes a novel approach to prevent fragility fractures in osteoporosis, skeletal complications of malignancy, and potentially bone erosions in rheumatoid arthritis (RA). In addition to being… CONTINUE READING


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