Do Pancreatic β Cells “Taste” Nutrients to Secrete Insulin?

@article{Henquin2012DoP,
  title={Do Pancreatic $\beta$ Cells “Taste” Nutrients to Secrete Insulin?},
  author={Jean-Claude Henquin},
  journal={Science Signaling},
  year={2012},
  volume={5},
  pages={pe36 - pe36}
}
  • J. Henquin
  • Published 2012
  • Biology, Medicine
  • Science Signaling
The role of β cell taste receptors in the control of insulin secretion is unclear. Insulin secretion from pancreatic β cells is controlled by nutrients, hormones, and neurotransmitters. Unlike the latter, which work through classic receptors, glucose and most other nutrients do not interact with membrane receptors but must be metabolized by β cells to induce insulin secretion. Studies have revealed the presence of umami and sweet taste receptors and their downstream effectors in β cells. That… Expand
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Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3
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Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling.
TLDR
Results reveal an important function of ATP signaling in pancreatic β-cells mediating fructose-induced hyper-responsiveness in insulinoma cells and isolated mouse and human pancreatic islets. Expand
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Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3.
TLDR
Results indicate that activation of the homodimer of T1R3 facilitates the metabolic pathway in mitochondria and augments ATP production and suggest that glucose, by acting on the homo-sensing receptor, promotes its own metabolism. Expand
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TLDR
The findings suggest that the OR system in pancreatic β-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism. Expand
Dose-dependent effect of glucose on GLP-1 secretion involves sweet taste receptor in isolated perfused rat ileum
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TLDR
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Dose-dependent effect of glucose on GLP-1 secretion involves sweet taste receptor in isolated perfused rat ileum [Rapid Communication].
TLDR
It is concluded that luminal glucose induced GLP-1 secretion from perfused rat ileum in a concentration-dependent manner, and this secretion was mediated by sweet taste receptor transducing signal for GLp-1 release on the gut of rat. Expand
Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states.
TLDR
The results indicate that T1R3 is expressed mainly in β-cells and the expression levels are different depending upon the nutritional and metabolic conditions. Expand
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