Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia?

@article{Broxterman1999DoPA,
  title={Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia?},
  author={HJ Broxterman and P. Sonneveld and Rob Pieters and Jan Lankelma and C. A. Eekman and AH Loonen and Martijn Schoester and G Ossenkoppele and Bob L{\"o}wenberg and H. M. Pinedo and GJ Schuurhuis},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={258-265}
}
Two proteins that have been correlated with the occurrence of multidrug resistance in acute myeloid leukemia (AML) are P-glycoprotein (Pgp) and the major vault protein (Mvp/LRP). With the purpose of further quantifying the potential contributions of Pgp-mediated drug efflux and Mvp/LRP to drug resistance in AML we have investigated whether the transport function of Pgp and the expression of Mvp/LRP correlated with the accumulation of daunorubicin (DNR) and the in vitro resistance to DNR… CONTINUE READING

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In vitro drug resistance may help to predict in vivo response or resistance to chemotherapy in adult AML patients

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