Do Non-Genomically Encoded Fusion Transcripts Cause Recurrent Chromosomal Translocations?

Abstract

We among others have recently demonstrated that normal cells produce "fusion mRNAs". These fusion mRNAs do not derive from rearranged genomic loci, but rather they are derived from "early-terminated transcripts" (ETTs). Premature transcriptional termination takes place in intronic sequences that belong to "breakpoint cluster regions". One important property… (More)
DOI: 10.3390/cancers4041036

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