Do Neonatal Mouse Hearts Regenerate following Heart Apex Resection?

  title={Do Neonatal Mouse Hearts Regenerate following Heart Apex Resection?},
  author={Ditte Caroline Andersen and Suganya Ganesalingam and Charlotte Harken Jensen and S\oren Paludan Sheikh},
  booktitle={Stem cell reports},
The mammalian heart has generally been considered nonregenerative, but recent progress suggests that neonatal mouse hearts have a genuine capacity to regenerate following apex resection (AR). However, in this study, we performed AR or sham surgery on 400 neonatal mice from inbred and outbred strains and found no evidence of complete regeneration. Ideally, new functional cardiomyocytes, endothelial cells, and vascular smooth muscle cells should be formed in the necrotic area of the damaged heart… CONTINUE READING
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