Do Leukotrienes (lt) Control Pulmonary Blood Flow (pbf) in the Fetal Lamd?


Pulmonary vascular resistance (PVR) is elevated in the fetus to maintain a low PBF. Lipooxygenase products of arachadonic acid metabolism, including LTC4 and LTD4, are potent pulmonary vasoconstrictors in adult animals. To evaluate whether LT contributes to the control of PVR and PBF in fetuses, the effects of LT inhibition were studied in 7 chronically… (More)
DOI: 10.1203/00006450-198404001-01526


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