Do L3T4+ T cells act as effector cells in protection against influenza virus infection.

@article{Lightman1987DoLT,
  title={Do L3T4+ T cells act as effector cells in protection against influenza virus infection.},
  author={Susan L. Lightman and Stephen Paul Cobbold and Herman Waldmann and Brigitte A. Askonas},
  journal={Immunology},
  year={1987},
  volume={62 1},
  pages={139-44}
}
This study aimed to analyse the roles of Lyt 2+ and L3T4+ memory T-cell subpopulations in murine influenza infection. Previous work has shown that Lyt 2+ cytotoxic T-cell (Tc) clones can adoptively transfer protection. We therefore wished to see whether L3T4+ (Th) cells could also act as protective effector cells. Donors for adoptive cell transfer were thymectomized mice, depleted in vivo of either Lyt 2+ or L3T4+ T cells with monoclonal antibodies (MAb) and then infected with influenza virus… CONTINUE READING