Do Glucocorticoids Cause Spinal Epidural Lipomatosis? When Endocrinology and Spinal Surgery Meet

  title={Do Glucocorticoids Cause Spinal Epidural Lipomatosis? When Endocrinology and Spinal Surgery Meet},
  author={Christian A. Koch and John L. Doppman and Nicholas J. Patronas and Lynnette K Nieman and George P. Chrousos},
  journal={Trends in Endocrinology \& Metabolism},

Symptomatic epidural lipomatosis in ectopic Cushing's syndrome.

In patients with severe neurological symptoms, surgical decompression of the myelum and removal of the epidural fat is the treatment of choice and routine imaging for the detection of epidural-located lipomatosis in patients at risk is probably useful.

Spinal Epidural Lipomatosis: A Comprehensive Review.

SEL is caused by an excess of adipose tissue accumulation localized to the thoracic and lumbar regions of the spine and may lead to neurological deficits, myelopathy, radiculopathy, neurogenic claudication, loss of sensation, difficulty voiding, lower extremity weakness, and rarely cauda equina syndrome.

Idiopathic Thoracic Spinal Epidural Lipomatosis With Relapsing And Remitting Symptoms

Conservative treatment is suggested for patients with minor symptoms, reserving surgical decompression for cases with progressive neurological deterioration, including patients with idiopathic SEL with relapsing and remitting course.

Myeloneuropathic Presentation of Spinal Epidural Lipomatosis

Spinal epidural lipomatosis (SEL) is accumulation of unencapsulated fat tissue within the epidural space of the spinal canal that may result in diagnostic confusion with other neuropathic or myelopathic conditions.

Idiopathic Spinal Epidural Lipomatosis in the Lumbar Spine.

The demographics and incidence of comorbidities of patients who underwent lumbar decompression for SEL vs degenerative stenosis without SEL were compared to show no differences in operative times, complications, or blood loss.

Spinal epidural lipomatosis – A brief review

Spinal epidural lipomatosis: a rare association of Cushing’s disease

A case of spinal epidural lipomatosis associated with Cushing’s disease, where a 17-year-old man was referred with lower limb weakness, weight gain, multiple stretch marks, back pain and loss of height made a good recovery following restoration of eucortisolism and a period of rehabilitation.

Spinal Epidural Lipomatosis: A Review of Pathogenesis, Characteristics, Clinical Presentation, and Management

Physicians should consider the underlying cause of SEL in a given patient before pursuing specific treatment modalities, but alarm symptoms, such as the development of acute cauda equina syndrome, should likely be treated with urgent surgical decompression.

Spinal epidural lipomatosis: a rare and frequently unrecognized complication of Cushing syndrome

A 29-year-old man who had severe CS secondary to an ACTH-secreting pituitary macroadenoma is presented with progressive lower limb weakness over a 2-year period leading to complete paraplegia in the last 4 months.

Spinal Epidural Lipomatosis -A case report-

Spinal epidural lipomatosis (SEL) is a rare condition of pathological overgrowth of fat tissue in the vertebral canal. SEL leads to back pain, radiculopathy or paraparesis. Glucocorticoids seem to



Idiopathic spinal epidural lipomatosis.

The experience suggests that idiopathic epidural lipomatosis may be a pathological entity that has been under diagnosed and surgical decompression remains the treatment of choice for the immediate relief of symptoms.

Symptomatic spinal epidural lipomatosis in a patient with Cushing's disease

It is suggested that in SEL of hypercortisolism, the excess of corticosteroids is the stimulus for the growth of adipose tissue in the spinal canal and that treatment should be aimed at correcting the endocrine abnormality.

Spinal epidural lipomatosis in a patient with the ectopic corticotropin syndrome.

A patient with spinal epidural lipomatosis who had the ectopic corticotropin syndrome is described who presented with severe back pain and weakness and had a cushingoid appearance, weakness of his hip flexor muscles, and bandlike hyperesthesia at level T6.

Childhood Presentation of Idiopathic Epidural Lipomatosis: A Case Report With Magnetic Resonance Imaging and Pathologic Confirmation

It is believed that the appearance of extrapyramidal findings-an awkward posture and bradykinesia, as well as gesture loss-were manifestations of a dystonia, which was mentioned earlier in association homocystinuria, but also of secondary parkinsonism that developed in association with homocyStinuria.

Spinal epidural lipomatosis as a complication of prolonged corticosteroid therapy.

A 42-year-old man who complained of low back pain radiating into the posterior aspect of both thighs revealed a Cushing's syndrome due to corticosteroid therapy for rheumatic polyarthritis, and surgical decompression produced immediate relief of symptoms.

Epidural Thoracic Lipomatosis Induced by Long-Term Steroid Treatment Case Illustration

A 78-year-old man with a marked disturbance of proprioception combined with spinal ataxia and an increasing loss of motor bladder control is treated for arteriitis temporalis with high dose steroid medication.

Spinal epidural lipomatosis in Cushing's syndrome secondary to an adrenal tumor

It is shown for the first time that the disease in Libyan Jews, although hereditary, is nevertheless transmissible, and the fact that only one of several inoculated animals developed disease, and had such a long incubation period, raises a question of whether the transmission resulted from the inoculum or from a cage infection.

Spinal epidural lipomatosis. Case report and review of the literature

This is a case report of lumbar epidural lipomatosis in a bodybuilder with radiculopathy supposedly induced by anabolic steroid intake.

Idiopathic Spinal Epidural Lipomatosis

The 18 year old girl was admitted with the complaints of back pain and weakness of lower extremities for 2 weeks and her motor strength and sensation returned to normal immediately after surgery.

Lymphomatous meningitis and steroid-induced epidural lipomatosis: CT evaluation.

This is the first case of epidural lipomatosis following chemotherapy for a malignancy, and Computed tomography was invaluable in diagnosis, despite the concomitant spinal lymphomatous leptomeningitis.