Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?

  title={Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?},
  author={Stephanie L Nott and Yanfang Huang and Brian R. Fluharty and Anna M Sokolov and Melinda Gingman Huang and Cathleen J Cox and Mesut Muyan},
  journal={Current pharmacogenomics and personalized medicine},
  volume={6 4},
Estrogen hormones play critical roles in the regulation of many tissue functions. The effects of estrogens are primarily mediated by the estrogen receptors (ER) alpha and beta. ERs are ligand-activated transcription factors that regulate a complex array of genomic events that orchestrate cellular growth, differentiation and death. Although many factors contribute to their etiology, estrogens are thought to be the primary agents for the development and/or progression of target tissue… CONTINUE READING
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