Do Electronic Cigarettes Have a Role in Tobacco Cessation?

  title={Do Electronic Cigarettes Have a Role in Tobacco Cessation?},
  author={Andrea S. Franks and Karen R. Sando and Sarah E. McBane},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long‐term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e‐cigarettes, are increasingly used for tobacco cessation. Because e‐cigarettes are widely used in this setting, health care professionals need to know if they are safe and effective. The purpose of this article is to review literature regarding use… 
13 Citations
A narrative review evaluating the safety and efficacy of e-cigarettes as a newly marketed smoking cessation tool
Evidence shows that e-cigarettes can have detrimental effects on several cell lines and animal models with their flavourings and nicotine content implicated; this has, however, not translated into major health outcomes after 3.5 years follow-up but has been linked to chronic lung disease and cardiovascular disease.
Electronic Cigarettes and Asthma: What Do We Know So Far?
Electronic cigarettes seem to worsen asthma symptoms and the rate and severity of exacerbations in asthmatics who are current vapers, whilst evidence suggests that its effectiveness as a smoking cessation tool might be limited.
Evaluation of Differential Oral Cell-specific Responses to the E-cigarette Component Nicotine
It is suggested that nicotine may have negative effects on both cellular viability and cellular proliferation among cancerous and non-cancerous cells, and these effects appear to become more pronounced over time, suggesting that short-term exposure to vaping solutions comprised of water with small amounts of nicotine may be sufficient to induce these effects.
Developments in smoking cessation interventions for patients with chronic obstructive pulmonary disease in the past 5 years: a scoping review.
Pharmacotherapy combined with behavioral interventions delivered via mHealth may be a promising strategy to help COPD smokers quit, but the overall quality of the current studies is poor, making it challenging for clinicians to make informed decisions.
Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes
Evidence is provided that the Opinion’s conclusions are not adequately backed up by scientific evidence and did not discuss the potential health benefits of using alternative combustion-free nicotine-containing products as substitute for tobacco cigarettes.
Carbon Monoxide and Small Hydrocarbon Emissions from Sub-ohm Electronic Cigarettes.
This study presents for the first time the mouthpiece emissions of carbon monoxide and small hydrocarbon gases, in addition to carbonyls, from a rebuildable atomizer sub-ohm device (SOD), and casts doubt on the validity of CO as a biomarker to distinguish ECIG from tobacco cigarette use.
Cancer Prevention Strategies for Women.
Primary prevention strategies-those aimed at reducing the risk of developing cancer-as well as secondary prevention strategies -measures aimed at the early detection of disease are examined.
The customizable e-cigarette resistance influences toxicological outcomes: lung degeneration, inflammation and oxidative stress-induced in a rat model.
The manipulation of e-cig resistance influences the carbonyls production from non-nicotine vapour and the oxidative and inflammatory status in a rat model, and suggests that certain "tips for vaping safety" cannot be established.


Electronic Cigarettes for Smoking Cessation
  • C. Bullen
  • Medicine
    Current Cardiology Reports
  • 2014
If patients who smoke are unwilling to quit or cannot succeed using evidence-based approaches, e-cigarettes may be an option to be considered after discussing the limitations of current knowledge.
Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study
The proposed medically assisted training program of e-cig use led to a successful nicotine intake, lack of typical cigarette craving and overdosage symptoms and a significant decrease in the biomarker of cigarette combustion products.
Electronic cigarettes for smoking cessation and reduction.
The main outcome measure was abstinence from smoking after at least six months follow-up, and was the most rigorous definition available (continuous, biochemically validated, longest follow- up).
Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study
The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit, and perception and acceptance of the product was good.
Use of electronic cigarettes among state tobacco cessation quitline callers.
This study offers a preliminary look at e-cigarette use among state quitline callers and is perhaps the first to describe e-cigarettes use in a large group of tobacco users seeking treatment.
E-cigarettes versus NRT for smoking reduction or cessation in people with mental illness: secondary analysis of data from the ASCEND trial
For people with mental illness, e-cigarettes may be as effective and safe as patches, yet more acceptable, and associated with greater smoking reduction.
Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study
Long-term e-Cigarette use can substantially decrease cigarette consumption in smokers not willing to quit and is well tolerated.
Evidence for harm reduction in COPD smokers who switch to electronic cigarettes
It is suggested that ECs use may aid smokers with COPD reduce their cigarette consumption or remain abstinent, which results in marked improvements in annual exacerbation rate as well as subjective and objective COPD outcomes.
Electronic cigarettes for smoking cessation: a randomised controlled trial
Electronic cigarette use among patients with cancer: Characteristics of electronic cigarette users and their smoking cessation outcomes
This article provides what to the authors' knowledge is the first published clinical data regarding E‐cigarette use and cessation outcomes among patients with cancer.