Do Electronic Cigarettes Have a Role in Tobacco Cessation?

@article{Franks2018DoEC,
  title={Do Electronic Cigarettes Have a Role in Tobacco Cessation?},
  author={Andrea S. Franks and Karen R. Sando and Sarah E. McBane},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2018},
  volume={38}
}
Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long‐term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e‐cigarettes, are increasingly used for tobacco cessation. Because e‐cigarettes are widely used in this setting, health care professionals need to know if they are safe and effective. The purpose of this article is to review literature regarding use… 
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12 Citations
Background Citations
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12 Citations

A narrative review evaluating the safety and efficacy of e-cigarettes as a newly marketed smoking cessation tool
TLDR
Evidence shows that e-cigarettes can have detrimental effects on several cell lines and animal models with their flavourings and nicotine content implicated; this has, however, not translated into major health outcomes after 3.5 years follow-up but has been linked to chronic lung disease and cardiovascular disease.
Effects of electronic cigarette aerosol exposure on oral and systemic health
Smoking Cessation and Vaping Cessation Attempts among Cigarette Smokers and E-Cigarette Users in Central and Eastern Europe
TLDR
The results indicate that while most university students have some desire to quit conventional smoking, those who use e-cigarettes do not have the same desire.
Electronic Cigarettes and Asthma: What Do We Know So Far?
TLDR
Electronic cigarettes seem to worsen asthma symptoms and the rate and severity of exacerbations in asthmatics who are current vapers, whilst evidence suggests that its effectiveness as a smoking cessation tool might be limited.
Evaluation of Differential Oral Cell-specific Responses to the E-cigarette Component Nicotine
TLDR
It is suggested that nicotine may have negative effects on both cellular viability and cellular proliferation among cancerous and non-cancerous cells, and these effects appear to become more pronounced over time, suggesting that short-term exposure to vaping solutions comprised of water with small amounts of nicotine may be sufficient to induce these effects.
E-Cigarette Markets and Policy Responses in Southeast Asia: A Scoping Review.
TLDR
Although Southeast Asia's e-cigarette market is relatively nascent, this is likely to change if transnationals invest more heavily in the region and regulatory action is needed to prevent e-cigarettes from becoming entrenched into these societies, especially among young people.
Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes
TLDR
Evidence is provided that the Opinion’s conclusions are not adequately backed up by scientific evidence and did not discuss the potential health benefits of using alternative combustion-free nicotine-containing products as substitute for tobacco cigarettes.
Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.
TLDR
It is shown that inhalation of e-cig vapor causes airway mucociliary dysfunction in vitro and in vivo, and it is suggested that the main nicotine effect on mucOCiliary function is mediated by TRPA1 and not nicotinic acetylcholine receptors.
Carbon Monoxide and Small Hydrocarbon Emissions from Sub-ohm Electronic Cigarettes.
TLDR
This study presents for the first time the mouthpiece emissions of carbon monoxide and small hydrocarbon gases, in addition to carbonyls, from a rebuildable atomizer sub-ohm device (SOD), and casts doubt on the validity of CO as a biomarker to distinguish ECIG from tobacco cigarette use.
Cancer Prevention Strategies for Women.
TLDR
Primary prevention strategies-those aimed at reducing the risk of developing cancer-as well as secondary prevention strategies -measures aimed at the early detection of disease are examined.
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References

SHOWING 1-10 OF 55 REFERENCES
Electronic Cigarettes for Smoking Cessation
  • C. Bullen
  • Medicine
    Current Cardiology Reports
  • 2014
TLDR
If patients who smoke are unwilling to quit or cannot succeed using evidence-based approaches, e-cigarettes may be an option to be considered after discussing the limitations of current knowledge.
Perceptions about e-cigarette safety may lead to e-smoking during pregnancy.
TLDR
It is postulate that the perception that e-cigarettes are safer during pregnancy may induce pregnant women to use these devices more freely, and the authors advocate for labeling of e-cigarette as potentially harmful, at least during pregnancy.
Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study
TLDR
The proposed medically assisted training program of e-cig use led to a successful nicotine intake, lack of typical cigarette craving and overdosage symptoms and a significant decrease in the biomarker of cigarette combustion products.
Correlates of Electronic Cigarettes Use Before and During Pregnancy
TLDR
The greater likelihood of electronic cigarette use compared to proven adjunctive smoking treatments suggests that electronic cigarettes should be examined as a potential aid to cessation in this population of smokers.
EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study
TLDR
In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects.
Electronic cigarettes for smoking cessation and reduction.
TLDR
The main outcome measure was abstinence from smoking after at least six months follow-up, and was the most rigorous definition available (continuous, biochemically validated, longest follow- up).
Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study
TLDR
The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit, and perception and acceptance of the product was good.
Use of electronic cigarettes among state tobacco cessation quitline callers.
TLDR
This study offers a preliminary look at e-cigarette use among state quitline callers and is perhaps the first to describe e-cigarettes use in a large group of tobacco users seeking treatment.
E-cigarettes versus NRT for smoking reduction or cessation in people with mental illness: secondary analysis of data from the ASCEND trial
TLDR
For people with mental illness, e-cigarettes may be as effective and safe as patches, yet more acceptable, and associated with greater smoking reduction.
Electronic cigarettes: human health effects
TLDR
While e-cigarette aerosol may contain fewer toxicants than cigarette smoke, studies evaluating whether e-cigarettes are less harmful than cigarettes are inconclusive and some evidence suggests that e- cigarette use may facilitate smoking cessation, but definitive data are lacking.
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