Do Alu repeats drive the evolution of the primate transcriptome?

@article{Urrutia2007DoAR,
  title={Do Alu repeats drive the evolution of the primate transcriptome?},
  author={Araxi O Urrutia and Leandro Balladares Oca{\~n}a and Laurence D Hurst},
  journal={Genome Biology},
  year={2007},
  volume={9},
  pages={R25 - R25}
}
Of all repetitive elements in the human genome, Alus are unusual in being enriched near to genes that are expressed across a broad range of tissues. This has led to the proposal that Alus might be modifying the expression breadth of neighboring genes, possibly by providing CpG islands, modifying transcription factor binding, or altering chromatin structure. Here we consider whether Alus have increased expression breadth of genes in their vicinity. Contrary to the modification hypothesis, we… CONTINUE READING

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Genome Biology 2008, 9:R25 http://genomebiology.com/2008/9/2/R25 Genome Biology 2008, Volume 9, Issue 2, Article

  • E Birney, D Andrews, +22 authors E Kulesha
  • Nucleic Acids Res
  • 2006
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