Do African and European ancestry and polymorphism of HLA class I play an important role in controlling HTLV-1 proviral load in admixed cohorts from Salvador, Brazil?

@inproceedings{Olavarria2014DoAA,
  title={Do African and European ancestry and polymorphism of HLA class I play an important role in controlling HTLV-1 proviral load in admixed cohorts from Salvador, Brazil?},
  author={Viviana Nilla Olavarria and Eduardo Jos{\'e} Melo dos Santos and Sidney Emanuel Batista dos Santos and Fernanda Grassi and Ramon Kruchewesky and Lu{\'i}s Crist{\'o}v{\~a}o de Moraes Sobrino P{\^o}rto and Xiaojan Gao and Mary N Carrington and Bernardo Galv{\~a}o-Castro},
  booktitle={Retrovirology},
  year={2014}
}
HAM/TSP is one of the most prevalent clinical manifestations of HTLV1 infection, likely related to high proviral load (PVL). We investigated HLA-A, -B and –C polymorphisms and determined the individual ancestry proportion of European, African and Amerindian in 209 HTLV-1 infected individuals in order to identify genetic factors that associate with HAM/TSP. The ancestry estimation using the STRUCTURE program considered the genotyping of 47 SNP ancestry markers. Using rigorous clinical and… CONTINUE READING