Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?

@inproceedings{Mnsson2018DoAS,
  title={Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?},
  author={Alf M{\aa}nsson and Marko U{\vs}aj and Luisa Moretto and Dilson E Rassier},
  booktitle={International journal of molecular sciences},
  year={2018}
}
In muscle, but not in single-molecule mechanics studies, actin, myosin and accessory proteins are incorporated into a highly ordered myofilament lattice. In view of this difference we compare results from single-molecule studies and muscle mechanics and analyze to what degree data from the two types of studies agree with each other. There is reasonable correspondence in estimates of the cross-bridge power-stroke distance (7⁻13 nm), cross-bridge stiffness (~2 pN/nm) and average isometric force… CONTINUE READING
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