Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis to Explaining Paradoxical Results.

  title={Do 5$\alpha$-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis to Explaining Paradoxical Results.},
  author={Abdulmaged M. Traish and Yonah Krakowsky and Gheorghe Doros and Abraham Morgentaler},
  journal={Sexual medicine reviews},
  volume={7 1},

Dutasteride add-on treatment to tadalafil for patients with benign prostatic enlargement is similarly effective as dutasteride add-on treatment to alpha blocker: a propensity-score matching analysis

The logistic regression analysis showed that PV at baseline and reduction rate of PV after treatment were associated with the effective symptomatic outcome, and the dutasteride add-on is a reasonable treatment option for male patients with LUTS who are not satisfied with tadalafil monotherapy.

OTT_A_262359 8813..8823

The data suggest that T induces human GBM progression through its conversion into DHT, which increases its affinity for AR and decreases five times the rate of dissociation compared to T.

Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines

The data suggest that T induces human GBM progression through its conversion into DHT, and it is possible that DHT mediates the effects of T on cell GBM cells motility by changing the expression of genes involved in tumor infiltration.

A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study.

It is suggested that LN18178 is a safe and tolerable herbal blend; it increases testosterone level and increases muscle strength and MUAC in young, healthy males.



The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.

It is demonstrated that the decrease in DHT induced by 5ARIs is associated with mild decreases in semen parameters that appear reversible after discontinuation.

5α-Reductase Type 1 Modulates Insulin Sensitivity in Men

Dutasteride and finasteride had similar effects on steroid profiles, with reduced urinary androgen and glucocorticoid metabolites and reduced circulating DHT but no change in plasma or salivary cortisol, and mRNA for 5 αR1 but not 5αR2 was detected in human adipose tissue.

Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial.

Changes in fat-free mass in response to graded testosterone doses did not differ in men in whom DHT was suppressed by dutasteride from those treated with placebo, indicating that conversion of testosterone to DHT is not essential for mediating its anabolic effects on muscle.

Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?

The state of art on this topic is summarized, the key unresolved questions that have emerged on the pharmacological targeting of these enzymes and their products are overview, and the need for further studies to ascertain the severity and duration of the adverse effects of 5α-R inhibitors, as well as their biological underpinnings is highlighted.

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

Analysis of the serum metabolome demonstrated that in the fasted state, dutasteride had a significant effect on lipid metabolism, and dual-SRD5A inhibition with dutasterside is associated with increased intrahepatic lipid accumulation.

Effects of finasteride (MK-906), a 5 alpha-reductase inhibitor, on circulating androgens in male volunteers.

Finasteride is well tolerated by normal volunteers and results in significant suppression of serum DHT at all doses tested, and the T/DHT ratio increased with all doses and returned to baseline when drug was discontinued.

The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

In this study, male subjects treated with 5 mg/day finasteride for 4 weeks had significantly decreased concentrations of DHT in bald scalp, resulting in a mean level similar to the baseline levels found in hair-containing scalp.