Dnmt3a restrains mast cell inflammatory responses.

@article{Leoni2017Dnmt3aRM,
  title={Dnmt3a restrains mast cell inflammatory responses.},
  author={Cristina Leoni and Sara Montagner and Andrea Rinaldi and Francesco Bertoni and Sara Polletti and Chiara Balestrieri and Silvia Monticelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 8},
  pages={E1490-E1499}
}
DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in DNMT3A correlate with mast cell proliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood. By using mast cells lacking Dnmt3a, we found that this enzyme is involved in restraining mast cell responses to… CONTINUE READING