Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

@inproceedings{Pitter2010Dnmt3aRE,
  title={Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens},
  author={Kenneth L. Pitter and Vincent Vialou and Herbert E. Iii Covington and Dani Dumitriu and Jian Feng and Brandon L. Warren and Ian S. Maze and David M Dietz and Emily L. Watts and Sergio D I{\~n}iguez and Ja Wook Koo and Ezekiell A Mouzon and William Renthal and Fiona Hollis and Hui Wang and Michele Ann Noonan and Yanhua Ren and Amelia J Eisch and Carlos Andr{\'e}s Mart{\'i}nez Bola{\~n}os and Mohamed Kamal Kabbaj and Guanghua Xiao and Rachael Lee Neve and Yasmin L Hurd and Ronald S. Oosting and Gouping Fan and John H Morrison and Eric J Nestler},
  booktitle={Nature Neuroscience},
  year={2010}
}
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use and chronic social defeat stress. Moreover, NAc-specific manipulations that block DNA methylation potentiated cocaine reward and exerted antidepressant-like effects, whereas NAc-specific Dnmt3a overexpression attenuated cocaine reward and was… CONTINUE READING
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