Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells.

  title={Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells.},
  author={Zhourui Wu and Kevin Huang and Juehua Yu and Thuc L Le and Masakasu Namihira and Yupeng Liu and Jun Zhang and Zhigang Xue and Liming Cheng and Guoping Fan},
  journal={Journal of neuroscience research},
  volume={90 10},
DNA methylation is known to regulate cell differentiation and neuronal function in vivo. Here we examined whether deficiency of a de novo DNA methyltransferase, Dnmt3a, affects in vitro differentiation of mouse embryonic stem cells (mESCs) to neuronal and glial cell lineages. Early-passage neural stem cells (NSCs) derived from Dnmt3a-deficient ESCs exhibited a moderate phenotype in precocious glial differentiation compared with wild-type counterparts. However, successive passaging to passage 6… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Clonal Hematopoiesis and Its Impact on Cardiovascular Disease.

Circulation journal : official journal of the Japanese Circulation Society • 2018

DNMT3A in Leukemia.

Cold Spring Harbor perspectives in medicine • 2017
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 27 references

DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2001
View 4 Excerpts
Highly Influenced

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.

Developmental dynamics : an official publication of the American Association of Anatomists • 2007
View 2 Excerpts
Highly Influenced

DNMT3A mutations in acute myeloid leukemia.

The New England journal of medicine • 2010

Similar Papers

Loading similar papers…