Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells.

@article{Wu2012Dnmt3aRB,
  title={Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells.},
  author={Zhourui Wu and Kevin Huang and Juehua Yu and Thuc L Le and Masakasu Namihira and Yupeng Liu and Jun Zhang and Zhigang Xue and Liming Cheng and Guoping Fan},
  journal={Journal of neuroscience research},
  year={2012},
  volume={90 10},
  pages={1883-91}
}
DNA methylation is known to regulate cell differentiation and neuronal function in vivo. Here we examined whether deficiency of a de novo DNA methyltransferase, Dnmt3a, affects in vitro differentiation of mouse embryonic stem cells (mESCs) to neuronal and glial cell lineages. Early-passage neural stem cells (NSCs) derived from Dnmt3a-deficient ESCs exhibited a moderate phenotype in precocious glial differentiation compared with wild-type counterparts. However, successive passaging to passage 6… CONTINUE READING

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