Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.

@article{Rinaldi2016Dnmt3aAD,
  title={Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.},
  author={Lorenzo Rinaldi and Debayan Datta and Judit Serrat and Lluis Morey and Guiomar Solanas and Alexandra Avgustinova and Enrique Blanco and Jos{\'e} Ignacio Pons and David Matallanas and Alex von Kriegsheim and Luciano Di Croce and Salvador Aznar Benitah},
  journal={Cell stem cell},
  year={2016},
  volume={19 4},
  pages={491-501}
}
The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown. Here, we show that in human epidermal stem cells, the two proteins bind in a histone H3K36me3-dependent manner to the most active enhancers and are required to produce their associated enhancer RNAs. Both proteins prefer super-enhancers associated to genes that either define the ectodermal lineage or establish the stem cell and differentiated states. However, Dnmt3a and Dnmt3b differ in… CONTINUE READING

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Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B

  • G. Rondelet, T. Dal Maso, L. Willems, J. Wouters
  • J. Struct. Biol
  • 2016
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