Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.

@article{Hervouet2009Dnmt3transcriptionFI,
  title={Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.},
  author={Eric Hervouet and François Marie Vallette and Pierre-François Cartron},
  journal={Epigenetics},
  year={2009},
  volume={4 7},
  pages={487-99}
}
Epigenetic gene inactivation in mammalian cells involves many silencing mechanisms. One of these mechanisms is the transcriptional repression by targeted promoter hypermethylation. However, the molecular mechanisms involved in the site-specific DNA (hyper)methylation are not fully elucidate. By using the Dnmt3a/c-myc interaction as an example, we here showed that this interaction promotes the site-specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a… CONTINUE READING