Dnmt2-dependent methylomes lack defined DNA methylation patterns.

  title={Dnmt2-dependent methylomes lack defined DNA methylation patterns.},
  author={Guenter Raddatz and Paloma M. Guzzardo and Nelly Olova and Marcelo Rosado Fantapp{\'i}{\'e} and Markus Rampp and Matthias Schaefer and Wolf Reik and Gregory J Hannon and Frank Lyko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 21},
Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA methyltransferase gene. However, information about Dnmt2-dependent methylation patterns has been limited to a few isolated loci and the results have been discussed controversially. In addition, recent studies have shown that Dnmt2 functions as a tRNA methyltransferase, which raised the possibility that Dnmt2-only genomes might be unmethylated. We have now used whole-genome bisulfite sequencing to analyze the… CONTINUE READING
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