DnaK promotes the selective export of outer membrane protein precursors in SecA-deficient Escherichia coli.

@article{Qi2002DnaKPT,
  title={DnaK promotes the selective export of outer membrane protein precursors in SecA-deficient Escherichia coli.},
  author={H Y Qi and Janine B Hyndman and Harris D Bernstein},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 52},
  pages={51077-83}
}
Consistent with many other results indicating that SecA plays an essential role in the translocation of presecretory proteins across the Escherichia coli inner membrane, we previously found that a approximately 95% depletion of SecA completely blocks the export of periplasmic proteins in vivo. Surprisingly, we found that about 25% of the outer membrane protein (OMP) OmpA synthesized after SecA depletion was gradually translocated across the inner membrane. In this study we analyzed the export… CONTINUE READING

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