DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis

@article{Boshoff2003DnaE2PC,
  title={DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis},
  author={H. Boshoff and M. B. Reed and C. Barry and V. Mizrahi},
  journal={Cell},
  year={2003},
  volume={113},
  pages={183-193}
}
  • H. Boshoff, M. B. Reed, +1 author V. Mizrahi
  • Published 2003
  • Medicine, Biology
  • Cell
  • The presence of multiple copies of the major replicative DNA polymerase (DnaE) in some organisms, including important pathogens and symbionts, has remained an unresolved enigma. We postulated that one copy might participate in error-prone DNA repair synthesis. We found that UV irradiation of Mycobacterium tuberculosis results in increased mutation frequency in the surviving fraction. We identified dnaE2 as a gene that is upregulated in vitro by several DNA damaging agents, as well as during… CONTINUE READING
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    References

    SHOWING 1-10 OF 74 REFERENCES
    DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability.
    • 11
    Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding.
    • 69
    • Highly Influential
    • PDF
    Characterization of Escherichia coli DNA lesions generated within J774 macrophages.
    • 107
    • PDF
    Error-prone repair DNA polymerases in prokaryotes and eukaryotes.
    • M. Goodman
    • Medicine, Biology
    • Annual review of biochemistry
    • 2002
    • 685
    • PDF
    Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis.
    • 104
    • PDF
    Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin
    • 642
    • PDF
    Two Essential DNA Polymerases at the Bacterial Replication Fork
    • 151
    • PDF
    Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
    • S. Ramaswamy, J. Musser
    • Biology, Medicine
    • Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
    • 1998
    • 1,049
    • PDF
    Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization.
    • 540
    • PDF