DnaA: controlling the initiation of bacterial DNA replication and more.

@article{Kaguni2006DnaACT,
  title={DnaA: controlling the initiation of bacterial DNA replication and more.},
  author={Jon M. Kaguni},
  journal={Annual review of microbiology},
  year={2006},
  volume={60},
  pages={351-75}
}
Escherichia coli is a model system to study the mechanism of DNA replication and its regulation during the cell cycle. One regulatory pathway ensures that initiation of DNA replication from the chromosomal origin, oriC, is synchronous and occurs at the proper time in the bacterial cell cycle. A major player in this pathway is SeqA protein and involves its ability to bind preferentially to oriC when it is hemi-methylated. The second pathway modulates DnaA activity by stimulating the hydrolysis… CONTINUE READING
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