Dna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent.

@article{Lee2003Dna2RF,
  title={Dna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent.},
  author={Kyoung-Hwa Lee and Myon Hee Lee and Tae Hoon Lee and Ji Won Han and Yong Jin Park and J. Ahnn and Y Seo and Hyeon-Sook Koo},
  journal={Molecules and cells},
  year={2003},
  volume={15 1},
  pages={81-6}
}
To determine the function of Dna2 in a multicellular organism, the Caenorhabditis elegans Dna2 expression was probed and deletion mutant phenotypes were analyzed. Dna2 was localized to the nuclei of C. elegans oocytes and early embryos by immunostaining or green fluorescent protein-tagging. A homozygous dna2 deletion mutant showed a reduced brood size and embryonic lethality, and the phenotypes greatly depended on growth temperature and aggravated in the succeeding generation. The mutant… CONTINUE READING

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