Dna Repair Defects Drive Genomic Instability and Tumor Immunogenicity

Abstract

DNA-damaging agents are widely used in clinical oncology and exploit defi ciencies in tumor DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic strategy, the interaction of tumor DNA damage with the immune system has recently come into focus, and it is now clear that the tumor DNA repair landscape has an important role in… (More)

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