Dmd067868 209..219


The thiouracil derivative PF-06282999 [2-(6-(5-chloro-2-methoxyphenyl)4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide] is an irreversible inactivator of myeloperoxidase and is currently in clinical trials for the potential treatment of cardiovascular diseases. Concerns over idiosyncratic toxicity arising from bioactivation of the thiouracil motif to… (More)


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@inproceedings{Dong2016Dmd0678682, title={Dmd067868 209..219}, author={Jennifer Q. Dong and M. Vishaal Varma and Angela C. Wolford and Tim F. Ryder and Li Di and Bo Feng and Steven G Terra and Kazuko Sagawa and Amit S. Kalgutkar}, year={2016} }