Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication.

@article{Beall2004DmmybML,
  title={Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication.},
  author={Eileen L. Beall and Maren Bell and Daphne Georlette and Michael R Botchan},
  journal={Genes & development},
  year={2004},
  volume={18 14},
  pages={1667-80}
}
Gene amplification at the chorion loci in Drosophila ovarian follicle cells is a model for the developmental regulation of DNA replication. Previously, we showed that the Drosophila homolog of the Myb oncoprotein family (DmMyb) is tightly associated with four additional proteins and that DmMyb is required for this replication-mediated amplification. Here we used targeted mutagenesis to generate a mutant in the largest subunit of the DmMyb complex, the Aly and Lin-9 family member, Myb… CONTINUE READING
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