• Corpus ID: 21096015

Dlx5 regulates regional development of the branchial arches and sensory capsules.

@article{Depew1999Dlx5RR,
  title={Dlx5 regulates regional development of the branchial arches and sensory capsules.},
  author={Michael J. Depew and J. K. Liu and Jason E. Long and Robert Presley and Juanito J. Meneses and Roger A. Pedersen and John L. R. Rubenstein},
  journal={Development},
  year={1999},
  volume={126 17},
  pages={
          3831-46
        }
}
We report the generation and analysis of mice homozygous for a targeted deletion of the Dlx5 homeobox gene. Dlx5 mutant mice have multiple defects in craniofacial structures, including their ears, noses, mandibles and calvaria, and die shortly after birth. A subset (28%) exhibit exencephaly. Ectodermal expression of Dlx5 is required for the development of olfactory and otic placode-derived epithelia and surrounding capsules. The nasal capsules are hypoplastic (e.g. lacking turbinates) and, in… 

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  • 2019
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