Dlx5, a positive regulator of osteoblastogenesis, is essential for osteoblast-osteoclast coupling.

@article{Samee2008Dlx5AP,
  title={Dlx5, a positive regulator of osteoblastogenesis, is essential for osteoblast-osteoclast coupling.},
  author={Nadeem Samee and Val{\'e}rie Geoffroy and Caroline Marty and Corinne Schiltz and Maxence Vieux-Rochas and Giovanni Levi and Marie-Christine de Vernejoul},
  journal={The American journal of pathology},
  year={2008},
  volume={173 3},
  pages={773-80}
}
The homeodomain protein Dlx5 is an activator of Runx2 (a key regulator of osteogenesis) and is thought to be an important regulator of bone formation. At present, however, the perinatal lethality of Dlx5-null mice has hampered the elucidation of its function in osteogenesis. Here we provide the first analysis of the effects of Dlx5 inactivation on bone development. Femurs of Dlx5-null mouse embryos at the end of gestation exhibit a reduction in both total and trabecular bone volume associated… CONTINUE READING

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