Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.

@article{Iso2006Dll4selectiveNS,
  title={Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.},
  author={Tatsuya Iso and Toshitaka Maeno and Yuichi Oike and Miki Yamazaki and Hiroshi Doi and Masashi Arai and Masahiko Kurabayashi},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={341 3},
  pages={708-14}
}
The Notch pathway is involved in multiple aspects of vascular development, including arterial-venous differentiation. Here, we show that Notch stimulation instructively induces arterial characteristics in endothelial cells (EC). Forced expression of Notch intracellular domain (NICD, activated form of Notch) induced mRNA expression for a subset of arterial… CONTINUE READING