Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma.

@article{Xu2012Dll1NotchAC,
  title={Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma.},
  author={Dehui Xu and Jinsong Hu and Elke De Bruyne and Eline Menu and Rik Schots and Karin Vanderkerken and Els Van Valckenborgh},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={428 4},
  pages={518-24}
}
One of the greatest challenges in multiple myeloma (MM) treatment is to overcome drug resistance. Many pathways are involved including Notch signaling. Notch receptors are expressed by MM cells and Notch ligand Dll1 is present on bone marrow (BM) stromal cells. In this study, we demonstrate that Dll1 can activate Notch signaling mostly through Notch2 receptor and can contribute to drug resistance to bortezomib, both in murine and human MM cells. Blocking the Notch pathway by DAPT (gamma… CONTINUE READING
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