DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest.

  title={DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest.},
  author={Yan X. Zhang and R A Mooney and Jeffrey A. Grass and Priya Sivaramakrishnan and Christophe Herman and Robert Landick and Jue D. Wang},
  journal={Molecular cell},
  volume={53 5},
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independently of local noise and used it to reveal that the transcription factor DksA inhibits promoter-proximal pausing and increases RNAP elongation when uncoupled from translation by depletion of charged… CONTINUE READING
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