Divorcing ARF and p53: an unsettled case

@article{Sherr2006DivorcingAA,
  title={Divorcing ARF and p53: an unsettled case},
  author={Charles J. Sherr},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={663-673}
}
  • C. Sherr
  • Published 1 September 2006
  • Biology, Medicine
  • Nature Reviews Cancer
Mammalian cells that sustain oncogenic insults can invoke defensive programmes that either halt their division or trigger their apoptosis, but these countermeasures must be finely tuned to discriminate between physiological and potentially harmful growth-promoting states. By functioning specifically to oppose abnormally prolonged and sustained proliferative signals produced by activated oncogenes, the ARF tumour suppressor antagonizes functions of MDM2 to induce protective responses that depend… 

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