Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

@inproceedings{Bachmann2011DivisionOL,
  title={Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range},
  author={Julie Bachmann and Andreas Raue and Marcel Schilling and Martin E. B{\"o}hm and Clemens Kreutz and Daniel Kaschek and Hauke Busch and Norbert Gretz and Wolf D. Lehmann and Jens Timmer and Ursula Klingm{\"u}ller},
  booktitle={Molecular systems biology},
  year={2011}
}
Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. The specific contributions of individual feedback regulators, however, remain unclear. Based on extensive time-resolved data sets in primary erythroid progenitor cells, we established a dynamic pathway model to dissect the roles of the two transcriptional negative feedback regulators of the suppressor of cytokine signaling (SOCS) family, CIS and SOCS3, in JAK2/STAT5 signaling… CONTINUE READING
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