Dividing the empire: boundary chromatin elements delimit the territory of enhancers.

@article{Udvardy1999DividingTE,
  title={Dividing the empire: boundary chromatin elements delimit the territory of enhancers.},
  author={Andor Udvardy},
  journal={The EMBO journal},
  year={1999},
  volume={18 1},
  pages={1-8}
}
Chromatin is the most complex supramolecular organization of the cell. It has a dual role: to compact the chromosomal DNA and to ensure a highly efficient regulation of gene expression. In consequence of the very compact packaging of the DNA, chromatin is highly repressive for transcription. Enhancers are key regulatory elements which can relieve the chromatin-induced repression. The interplay between the chromatin-mediated repression and the activating function of enhancers ensures that the… CONTINUE READING