Divide and conquer: the E2 active site

  title={Divide and conquer: the E2 active site},
  author={Puck Knipscheer and Titia Sixma},
  journal={Nature Structural &Molecular Biology},
VOLUME 13 NUMBER 6 JUNE 2006 NATURE STRUCTURAL & MOLECULAR BIOLOGY two consecutive spliceosomal conformations must depend on their relative stabilities, the rate of any given rearrangement would depend on the activity and/or concentration of factors interacting with the spliceosome in each of these two conformations3. Thus, Prp22 is unlikely to represent a unique fidelity factor for the 3′ SS or more generally for secondstep catalysis; rather, one would expect other factors that modulate the… CONTINUE READING