Diversity-oriented synthesis of macrocyclic peptidomimetics

  title={Diversity-oriented synthesis of macrocyclic peptidomimetics},
  author={Albert Isidro-Llobet and Tiffanie Murillo and P. Bell{\'o} and A. Cilibrizzi and J. Hodgkinson and W. Galloway and A. Bender and M. Welch and D. Spring},
  journal={Proceedings of the National Academy of Sciences},
  pages={6793 - 6798}
  • Albert Isidro-Llobet, Tiffanie Murillo, +6 authors D. Spring
  • Published 2011
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of diverse small molecules based around a common macrocyclic peptidomimetic framework, containing structural motifs present in many naturally occurring bioactive compounds. Macrocyclic peptidomimetics are largely underrepresented in current small-molecule screening collections… CONTINUE READING
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