• DOI:10.1038/ncomms1081
Corpus ID: 15338166

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

@article{Galloway2010DiversityorientedSA,
  title={Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.},
  author={W. Galloway and Albert Isidro-Llobet and D. Spring},
  journal={Nature communications},
  year={2010},
  volume={1},
  pages={
          80
        }
}

W. Galloway, Albert Isidro-Llobet, D. Spring

Published 2010

Biology, Medicine

Nature communications

Biologically active molecules can be identified through the screening of small-molecule libraries. Deficiencies in current compound collections are evidenced by the continuing decline in drug-discovery successes. Typically, such collections are comprised of large numbers of structurally similar compounds. A general consensus has emerged that library size is not everything; library diversity, in terms of molecular structure and thus function, is crucial. Diversity-oriented synthesis (DOS) aims… CONTINUE READING

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