Diversity of the mammalian sodium/proton exchanger SLC9 gene family

  title={Diversity of the mammalian sodium/proton exchanger SLC9 gene family},
  author={J. Orlowski and S. Grinstein},
  journal={Pfl{\"u}gers Archiv},
  • J. Orlowski, S. Grinstein
  • Published 2004
  • Biology, Medicine
  • Pflügers Archiv
  • Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in most, if not all, living organisms. In mammals, these transporters chiefly catalyze the electroneutral exchange of Na+ and H+ down their respective concentration gradients and are crucial for numerous physiological processes, ranging from the fine control of intracellular pH and cell volume to systemic electrolyte, acid-base and fluid volume homeostasis. NHE activity also facilitates the progression of other… CONTINUE READING
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