Diversity of the apoptotic response to chemotherapy in childhood leukemia

  title={Diversity of the apoptotic response to chemotherapy in childhood leukemia},
  author={T Liu and Elizabeth A. Raetz and P Moos and S Perkins and C Bruggers and Fiona Smith and WL Carroll},
Apoptosis is the primary mechanism through which most chemotherapeutic agents induce tumor cell death. The purpose of this study was to determine the extent to which blasts from children with leukemia undergo a uniform apoptotic death pathway in vivo. The expression of pro- and anti-apoptotic proteins p53, p21, MDM-2, BCL-2, BCL-XL, BCL-XS, and BAX, and caspase-3 activity was determined in circulating blasts collected from the peripheral blood of children with leukemia prior to, and at serial… CONTINUE READING
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Long - term results of treatment studies for childhood acute lymphoblastic leukemia

  • KW Malmey, JJ Shuster, S Murphy, J Pullen, B Camitta
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