Diversity of the MBL2 gene in various Brazilian populations and the case of selection at the mannose-binding lectin locus.

@article{Boldt2006DiversityOT,
  title={Diversity of the MBL2 gene in various Brazilian populations and the case of selection at the mannose-binding lectin locus.},
  author={Angelica BW Boldt and Lod{\'e}rcio Culpi and Luiza Tamie Tsuneto and Il{\'i}ada Rainha de Souza and J{\"u}rgen F. J. Kun and Maria Luiza Petzl-Erler},
  journal={Human immunology},
  year={2006},
  volume={67 9},
  pages={
          722-34
        }
}
The mannose binding lectin (MBL2) polymorphism is responsible for a common immunodeficiency in the human species. There were suggestions that the MBL2 polymorphism has been under balancing selection, based on the high global frequency of alleles generating MBL deficiency and on the worldwide distribution of diseases negatively associated with them. To describe the distribution of MBL2 allelic haplotypes in Brazilian populations and to discuss the evolution of this polymorphism, we analyzed six… CONTINUE READING

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