Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases.

@article{Alyanakian2003DiversityOR,
  title={Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases.},
  author={Marie-Alexandra Alyanakian and Sylvaine You and Diane Damotte and Christine Gouarin and Anne Esling and Corinne Garcia and S{\'e}verine Havouis and Lucienne Chatenoud and J. -F. Bach},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 26},
  pages={15806-11}
}
Depletion of selected regulatory CD4+ T cell subsets induces the spontaneous onset of various immune or autoimmune disorders. It is not clear, however, whether a given subset, notably CD4+CD25+ regulatory T cells, protects from a wide spectrum of immune disorders, or whether specialized subsets of regulatory T cells control each given disease or group of diseases. We report here, using diabetes prone nonobese diabetic (NOD) mice, that depending on the regulatory T cells that are depleted, i.e… CONTINUE READING